Develop

Key technologies to rapidly and robustly reveal key regulatory elements in cancer at the single cell resolution

Scale

Massively increase scale of single cell genomics, up to 10-100 million single cells, at low cost for population scale functional genomics

Automate

Dully-automate hyper-scale single cell genomics (eg. molecular phenotyping) for small molecule, ASO, CRISPR libraries

Translate

Discovery and characterization of functional regulators of Super-Enhancers based on Nucleic Acids and other modalities

what we do

Regulatory Genomics 
at the single cell resolution

The 98% of the human genome is non-coding and was once considered ‘junk’ but we now know that they play a critical role in human development and disease. Identifying and controlling these non-coding regulatory elements create untapped opportunities for precision medicine, clinical diagnosis and medical interventions. 

Specifically, the lab decodes the genome by developing break-through genomic technologies and expandable automations for large-scale assays. By combining experimental and computational approaches, the lab uncovers non-coding DNA and RNA elements in cancer and target them based on next-generation therapeutics including nucleic acids and genome-editing tools.

The lab actively participates in the Human Cell Atlas (HCA) and FANTOM consortiums, creating possibilities to engage with the global community to illuminate noncoding regulatory elements in disease.

As recommended by different members of the lab.

Helpful resources

Recommended readings
  • What is single-cell genomics, how it works
  • Why single-cell genomics
  • Non-coding DNA/RNA (enhancers/repressors)
  • 5' sequencing
  • Long reads
  • Spatial
  • What is a UMAP?

Join us!

You are welcome to apply through the A*STAR Careers Portal, or apply informally via email

A*STAR Careers Portal

For prospective students

 Graduate Students

Singapore International Graduate Award (SINGA)

Upon successful completion, students will be conferred a PhD degree by either NTU, NUS, SUTD or SMU. It is a bond-free award offered to international students. 

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A*STAR Research Attachment Programme (ARAP)

Under this programme, PhD students from overseas universities will spend one to two years at A*STAR Research Institutes under the joint supervision of A*STAR researchers and faculty members of their home universities.

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A*STAR Graduate Scholarship (AGS)

The AGS will finance up to four years of your PhD or EngD studies at an autonomous universities in Singapore. After completing their studies, AGS scholars can apply to pursue post-doctoral training overseas to further deepen their research expertise and expand their global network.

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 Internships

A*STAR Research Internship Award (ARIA)

ARIA provides undergraduates an exciting opportunity to sharpen your research skills and discover your passion in scientific research.

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Singapore International Pre-Graduate Award (SIPGA)

International 3rd and 4th year undergraduate and master’s students who are pursuing their bachelor’s or master’s degree in Computing and Information Science, Biomedical Science, Physical Science or Engineering and Technology can apply for attachments of two to six months in duration. 

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