Key technologies to rapidly and robustly reveal key regulatory elements in cancer at the single cell resolution
Massively increase scale of single cell genomics, up to 10-100 million single cells, at low cost for population scale functional genomics
Dully-automate hyper-scale single cell genomics (eg. molecular phenotyping) for small molecule, ASO, CRISPR libraries
Discovery and characterization of functional regulators of Super-Enhancers based on Nucleic Acids and other modalities
The 98% of the human genome is non-coding and was once considered ‘junk’ but we now know that they play a critical role in human development and disease. Identifying and controlling these non-coding regulatory elements create untapped opportunities for precision medicine, clinical diagnosis and medical interventions.
Specifically, the lab decodes the genome by developing break-through genomic technologies and expandable automations for large-scale assays. By combining experimental and computational approaches, the lab uncovers non-coding DNA and RNA elements in cancer and target them based on next-generation therapeutics including nucleic acids and genome-editing tools.
The lab actively participates in the Human Cell Atlas (HCA) and FANTOM consortiums, creating possibilities to engage with the global community to illuminate noncoding regulatory elements in disease.
As recommended by different members of the lab.
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